Zone of hypertrophy and calcification . 1)zone of reserve cartilage, 2)proliferation, 3)maturation, 4)hypertrophy, 5)degeneration, 6)ossification Definition list the zones in the epiphyseal plate (6-in order epiphysis to diaphysis) Once cartilage cannot grow further, the structure cannot elongate more. Articular cartilage progenitor cells (ACPCs) usually exist in one third of the superficial zone of articular cartilage. 1. zone of resting cartilage 2. zone of proliferating cartilage 3. zone of hypertrophic cartilage 4. zone of calcified cartilage. (calcification kills chondrocytes and matrix appears opaque). EXTRACELLULAR MATRIX OF BONE OSTEOID - MIXTURE OF TYPE I COLLAGEN AND COMPLEX MATRIX MATERIAL TO INCREASE THE AFFINITY AND SERVE AS NUCLEATION SITES Zone of hypertrophic cartilage A. Chondrocytes stop dividing and start to hypotrophy (enlarge). Zone of calcified cartilage A. 5. this layer consists of large, maturing chondrocytes arranged in columns. On the diaphyseal side of the growth plate, cartilage calcifies and dies, then is replaced by bone (figure 6.43, zones of hypertrophy and maturation, calcification and ossification). B. Lacunae walls become thin as the chondrocytes resorb matrix during hypotrophy. . hyaline cartilage anchors growth plate to bone. .hypertrophied chondrocytes dying or lysed away, matrix material calcified, invasion of capillaries osteogenic cells. Narrow zone of cartilage only a few cells thick B. Zone of Hypertrophic Cartilage a. Layer consists of cells that are getting larger and are still shaped like stacked coins 4. Zone of calcified cartilage. cell division ceases, chondrocytes increase in size. 3. d. Zone of calcified cartilage ο only a few cells thick, ο ο only a few cells thick, ο 4. This preview shows page 121 - 125 out of 225 pages.. c. Zone of Hypertrophic cartilage ο extremely large chrondrocytes that are arranged in columns, ο maturing cells. Blood vessel invasion was almost completely suppressed, concomitant with impaired trabecular bone formation and expansion of hypertrophic chondrocyte zone. Metaphyseal (osteogenic) zone . 4. As cartilage grows, the entire structure grows in length and then is turned into bone. 3. Zone of Calcified Cartilage Articular cartilage can be divided into four zones depending on the collagen and proteoglycan organization and content: the superficial zone, the transitional zone, the middle (radial) or deep zone, and the calcified cartilage zone (Fig. Zone of maturing cartilage . Zone of hypertrophic cartilage. Describe the zone of resting cartilage in the epiphyseal plate? Zone of resting/ reserve cartilage Zone of proliferation Zone of hypertrophy Zone of ossification Zone of calcification bone . only a few cells thick and consists mostly of chondrocytes thst are dead because the ECM around them has calcified. 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