At some point, he was appointed as foreman for an assignment at the strip mine. Praxis seized the throne of Haven City by force during the height of the Metal Head Wars by betraying King Damas, who was the rightful monarch of the city as the descendant of Mar, the founder of Haven City. Although strictly speaking polycythemia implies a rise of all blood cell counts above normal, the occurrence of leukocytosis and thrombocytosis along with erythrocytosis is exceptionally rare in companion animals. https://jakanddaxter.fandom.com/wiki/Vin?oldid=135647. During the Metal Head invasion in the latter part of Jak II, Vin alerted Jak that it was Kor who sabotaged the Shield Wall. He helped Jak and Daxter retrieve the artifact to unlock the doors at the KG war factory. He has a constant fear of Metal Heads and is a bit crazy. Neurologic signs are the most common presenting complaints, but with the advent of more frequent health screens including complete blood cell counts, the erythrocytosis may be discovered earlier as an incidental finding. ET patients harboring the JAK2 V617F mutation were more likely to develop AVWS than were calreticulin-positive patients (70.3% vs. 45.7%, P=0.02), despite lower platelet counts (median 773 vs. 920×10 9 /L, P=0.05). Clinical experience, however, suggests that P. vera may occur rarely compared to other forms of polycythemia. Ashelin voiced by Susan Eisenberg and 3 others . 5 (4) 4 (0) 3 (1) 2 (0) 1 (0) 4.6 stars. New insight into the causes of primary and secondary polycythemias has been gained in human and veterinary medicine. Jak and Daxter Wiki is a FANDOM Games Community. What the users think. Oops! Damas was banished to the Wasteland. The rules here are the same as before. School of Veterinary MedicineUniversity of PennsylvaniaPhiladelphia, PA, USA. If possible, renal and other tumors/masses should be removed or treated and cardiopulmonary distress should be corrected. Jak II is a real departure from the formula that was set up in the first Jak and Daxter game. In fact, patients with absolute polycythemia often have an expanded blood volume. This is, however, rarely if ever needed in clinical practice, as dehydration can be readily excluded as cause of relative polycythemia. Ashelin said. In fact, animals with a presumptive diagnosis of primary polycythemia as well as cases with an early presentation in life that continues over a chronic course of many years, point strongly to the existence of other forms of primary polycythemia in dogs and cats. While there, the location was attacked by Metal Heads and Vin barricaded himself inside a control room as protection from them. He is the founder of the ruling dynasty in Haven City, the House of Mar , with the family crest and Precursor artifact known as the Seal of Mar . The other one is behind the first well (if you took my advice above) and can be accessed by taking the path around the Dark Eco lake on the side of Vin's hideout. Baron Praxis used the strip mine as some means to provide such eco to the Metal Heads by installing eco wells and leaving them open for the taking, under the pretense to the people that he would eventually pipe them into the eco gridfor the city. Oh, the fun we'll have."[4]. Later, Jak first visited the strip m… Just click, Polycythemia—Diagnostics and Management of a High Hematocrit, World Small Animal Veterinary Association Congress Proceedings, 2018, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA, VINcyclopedia of Diseases (Formerly Associate), Books & VINcyclopedia of Diseases (Formerly Associate), Alternative Medicine, Homeopathy and Acupuncture, TDP Lamp & Herbal Medicine for Tan-Huan Syndrome, Maximizing Quality of Life of Ill Patients, Veterinary Nurses & Optimizing Animal Welfare, Aquatic Pet Medicine and World Rabies Day, Rabies Vaccination of Dogs to Protect People, Single Donor Canine Platelet Transfusions, Therapeutic Outcomes of Injectable Filgrastim, CT Appearance of Caudal Abdominal Lymphocenter, Morphometric Measurements of Brain Fourth Ventricle, Periodontal Disease in Yorkshire Terrier Dog, Optimize Urinary Bladder Ultrasound Imaging, Glucocorticoid-Deficient Hypoadrenocorticism, Electrocardiographics Parameters of Chelonoidis, Chronic Kidney Disease & Protein Restriction, Obstructive Feline Lower Urinary Tract Disease, Causes of Death of Cats in Veterinary Hospital, Prevalence of Gastrointestinal Diseases in Cats, Commercial FeLV Nucleic Acid Detection Kits, Glycogen Storage Disease Associated Hypoglycemia, Effect of Pancreatic Lipase-Related Proteins, Rapid Serological Tests for Ehrlichia canis, Fecal Sampling for Parvovirus PCR Detection, Bacterial & Viral Upper Respiratory Infections, Parasitic & Bacterial Infectious Diarrhea, Canine Infectious Respiratory Disease Complex, Idiopathic Anemia with Severe Thrombocytopenia, 2,3-Diphosphoglycerate Levels in Packed RBC, Treat Fractures with Minimally Invasive Techniques, Hemodialysis in Chronic Kidney Disease Dogs, Canine Vertebral Screw & Rod Fixation System, Best Practice for Collection, Testing & Understanding of Blood Results, Docosahexaenoic Acid in Microalgae Schizochytrium, Nutrition & Management of Feline Diseases, Mastocytoma & Mammary Tumors Fatty Acid Profile, Electromagnetic Thermoablation for Oral Tumors, Leptin & Leptin Receptor in Mammary Tumors, Serodetection & Risk Analysis of Leptospiral Infection, Seroprevalence of Borrelia Infections in Dogs, Radiotherapy, Exenteration, Partial Orbitectomy, Uveitis is Just Intraocular Lymphadenopathy, Performance of Intraocular Lens Implantation, Using Cerclage Wire in Fracture Treatment, Demineralized Freeze-Dried Bone Allograft, Reason for Deaths of New Zealand White Rabbits, Clinical Use of Aglepristone in Bitches & Queens, Deslorelin to Control Reproduction in Cats, Presentation, Diagnosis, Treatment of Pyometra, Low Density Tubular Bovine Collagen Graft, Surgical Occlusion with Cellophane Bands Methods, Subcutaneous vs. Sublingual Immunotherapy, New Concepts of Staphylococcal Infections, Chronic Upper Respiratory Tract Disease in Cats, Peculiarities of Feline Hyperadrenocorticism, Cognitive Dysfunction Syndrome & Acupuncture, Choosing the Right Organizational Structure, Using Clinic’s Data to Improve Compliance, Physical Modalities Used in Rehabilitation, Physiotherapy Terminology & Manual Therapies, Rehabilitation of Pediatric Canine Disorders. Cyanosis or renal size abnormalities may suggest a particular organ failure as well as mechanism, and define the type of the polycythemia. Appropriate PCV rises are seen in high altitudes and with cardiopulmonary disease such as congenital heart defects with right to left shunts (ventricular septal defects, reversed PDA, Tetralogy of Fallot) and rarely chronic obstructive pulmonary diseases. Hence, the diagnosis of P. vera is still based on the exclusion of other causes of … Vin is a support character in Jak II and Jak 3. Splenic contraction is an unlikely cause in dogs and cats, as it only marginally increases the PCV. Vin Art . JAK 2 El Renegado - Cap.6 - Salvando a VIN! It is revealed that Vin dumped his brain into the eco grid prior to his death, so he could exist as a "multi-layered hyper linking digi-memoc-bio-construct-super-clocked-mega-memory-construct"[2]—i.e. There are 2 Eco Wells that are hidden in newly opened areas: One is located behind the building where Vin used to hide before you rescued him. 30:27. This time, however, Daxter speaks up, and the leader - better known as Keira - … However, Damas' son (later revealed to be Jak before he was sent to the past) escaped. Back at Keira's garage, Jak gets a little steamed after Keira talks fondly of Erol and walks away, leaving Daxter to win the class 2 race on his own. Brutter voiced by Alan Blumenfeld and 5 others . Because of an underappreciation of the normal upper limit of the PCV in cats (48%) versus dogs (56%), polycythemia is generally underdiagnosed in cats. They include hyperemic or cyanotic mucous membranes (due to cardiopulmonary disorders and methemoglobinemia), hemorrhage (epistaxis and hyphema), and neurologic disturbances such as lethargy and seizures. He was chosen to protect the planet by the Precursors and helped build many relics and structures seen throughout both Jak II and Jak 3, including the Shield Wall and eco grid. The author is the director of the non-for-profit PennGen Laboratory which is offering genetic, hematological and blood typing and compatibility testing. "So, our newest recruit saved you." Jak II Art Gallery. Vin is a very skilled technician and computer operator, stabilizing the eco grid and Shield Wall from the power station, as well as maintaining other Haven City technology. This may be considered an appropriate response in which the erythron is responding normally to generalized tissue hypoxia or inappropriate in which the erythropoiesis is being stimulated by an aberrant production of erythropoietin or due to local renal hypoxia. He possesses an Econecic Energy Doctorate, for which he wrote on Precurian theoretical physics.[5]. The clinical signs of relative polycythemia are easily recognized and will not be further discussed here. Various renal tumors, including nephroblastomas and carcinomas, may result in renal hypoxia and thereby cause elevations in serum erythropoietin and, consequently, inappropriate secondary polycythemia; whereas erythropoietin-producing tumors in other tissues have rarely been documented. Cats with cardiac shunting usually die before they can develop signs of polycythemia. One of the newest and most promising treatments for MF is … In most cases increased serum erythropoietin concentrations were documented or an association was established based upon the resolution of the polycythemia following the resection of the mass in animals and humans. "I didn't need saving, Torn." The bone marrow aspirate is consistent with erythroid hyperplasia, but is not diagnostic for a myeloproliferative disease in humans. He was the operator of the power station in Haven City, and a close ally of the Underground movement, described as one of their best informants.[1]. Polycythemic animals will not show clinical signs until the PCV reaches >60% with some of the highest PCVs exceeding 85%. Ever since Praxis had been looking for the child as he knew the boy would become the next rightful heir to the throne. Based upon blood volume and red cell mass, polycythemia can be divided into relative and absolute polycythemias, which represent completely different conditions, both requiring immediate but opposing therapeutic interventions. Vin voiced by Robert Patrick Benedict and 2 others . The metal heads eventually overran Vin at the power station, and during (what was implied to be) his last few words, Vin sent a transmission to Jak telling him to check the construction site for Kor. FRANCHISE RELATED. Vin, California, an unincorporated community in the US; Saint Vincent and the Grenadines (country code) The JAK2 enzyme has been the focus of research lately for treatment for myelofibrosis (MF). CU offers 5 ways to follow us so your news feed will never lack new art and inspiration. Serum erythropoietin values, determined by a species-validated assay, may be elevated in cases of secondary polycythemia, but a normal to low erythropoietin level does not rule out secondary polycythemia. Language: English Location: United States Restricted Mode: Off Jak goes to the Power Room and jump through the Warp Gate to Strip Mine to find and rescue Vin as the Metal Heads attacks. The target hematocrit is higher in dogs than in cats, as well as in cases with cardiopulmonary disease, but generally is greater than 50%. Animals treated with chemotherapy need to be monitored, not only by PCV measurements as for phlebotomized patients, but also by complete blood cell counts to identify drug induced cytopenias. In humans with P. vera, Jak-2 mutations have been documented and in a couple of dogs Jak-2 mutations have been found but the test for Jak-2 mutation is not clinically available in veterinary medicine. Vin's most distinctive and impressionable personality trait is his frenetic and paranoid nature. Bay non kèk nan zanmi Jewova te genyen. "[3] However he also implies that he is lonely, "If you fail, I can always use a companion in here. Menu. Animals with methemoglobin reductase deficiency may not need to be treated except during severe stress situations with methylene blue (1 mg/kg IV once). Vin. Chemotherapy with hydroxyurea at 10–25 mg/kg twice daily to once every other day is commonly used. In humans with P. vera, Jak-2 mutations have been documented and in a couple of dogs Jak-2 mutations have been found but the test for Jak-2 mutation is not clinically available in veterinary medicine. Sometime before the events of Jak II, Baron Praxis, the leader of Haven City, made a deal with Metal Head leader Metal Kor that he would provide them with eco so long as they attack the city only enough to justify his unjust placement in rulership. Listen to all the actors who have voiced the following Jak II characters. However Vin is also very modest, giving credit to Mar when Jak says he is a genius at what he does. From that point on, Vin could be seen at the power station operating computers, and would occasionally send Jak on missions at the strip mine and drill platform, two of which involved clearing these locations from metal head eggs. In emergency situations, patients with relative polycythemia will respond to fluid therapy, whereas patients with absolute polycythemia may need to be treated by phlebotomy. Polycythemic animals may remain asymptomatic for weeks to years and, in some cases, can be successfully managed for years. Welcome to Jak II HD!Originally released as Jak II: Renegade in 2003 on the Playstation 2, this HD re-release gives you the chance to join Jak and Daxter on their second adventure in the series, which is set in the city of New Haven far into the future from the previous game. Torn said, it wasn't a question. Please enter a valid Email address! P. vera, therefore, results in the accumulation of morphologically normal red blood cells, and less commonly white cells and platelets, and their progenitor cells in the absence of a definable stimulus. He also grows large, black claws, and during Ja… In humans with P. vera, Jak-2 mutations have been documented and in a couple of dogs Jak-2 mutations have been found but the test for Jak-2 mutation is not clinically available in veterinary medicine. Jak II 124% complete walkthrough. Tips from the Experts for the Management of... Bacterial Isolation from Urinary Tract Infections, Lower Urinary Tract Disorders in Boxer Dogs, Adverse Effects of Rapid Fluid Administration, Anesthesia & Pain Management for Dentistry, Dental Radiology Techniques & Interpretation, Role of Animal Shelters in Disaster Management. Techno Babble: Vin spouts a ton of this when Jak doubts his ability to activate the palace's old elevator system. More difficult is the differentiation of absolute polycythemia into primary or secondary polycythemia, which depends on whether the condition is erythropoietin independent or dependent. 2003's "Jak II" is a Naughty Dog release, and a sequel to their prior release "Jak and Daxter: The Precursor Saga." KIYÈS ou vle kòm zanmi w? Inappropriate secondary polycythemia of renal origin may also be rarely caused by amyloidosis, polycystic kidney disease, glomerulonephritis, and renal fibrosarcoma and lymphoma. Vin mentions that he is happier inside his computer system, stating that "those monsters [metal heads] can't get me in here! Primary polycythemia appears erythropoietin independent and has often been considered synonymous with P. vera in small animals, although additional forms of primary polycythemia need to be considered. Take your favorite fandoms with you and never miss a beat. Absolute or true polycythemia is characterized by an expanded red blood cell mass. In severely polycythemic patients repeated phlebotomies at no more 20 ml/kg (10 ml in cats) per session with or without simultaneous fluid replacement is the initial approach to lower the PCV to <60%. However, a bone marrow aspirate for cytologic examination adds no new information, since it fails to differentiate between primary and secondary polycythemias: the myeloproliferative disease resulting in P. vera has no characteristic cytologic or pathologic features of malignancy. Yon moun ou renmen. Rescue Vin at Strip Mine (**) ----- This is the first time you can choose which mission you take. Polydipsia and -uria and splenomegaly has been seen in animals assumed to have P. vera and rarely with other polycythemias. Vin, a character in the video games Jak II and Jak 3; Vin, the primary character in the Mistborn series by Brandon Sanderson; Vin Gonzales, a Spider-Man/Marvel Comics supporting character; Vin Petrol, a character in the Corner Shop Show; Places. Dark blood may be exposed to air to determine if it is deoxyhemoglobin or methemoglobin. Yon moun san w ale avè l e san l ale avè w. Yon moun ki gen yon bèl pèsonalite ak yon seri kalite ou apresye. Hence, polycythemia would be more appropriately called erythrocytosis and clinically refers to an increase to an above normal red blood cell count, hematocrit or packed cell volume (PCV), and hemoglobin (Hb) concentration. He was the operator of the power station in Haven City, and a close ally of the Underground movement, described as one of their best informants. There are no cytologically characteristic features of the bone marrow cells in P. vera as hematopoietic cells appear to fully mature. As relative polycythemias are readily recognized, confirmation of a normal blood volume may not be required in clinical practice. While there, Vin appears. Released in November 2003, Jak II is the acclaimed sequel to Jak and Daxter. Vin is a scientist who sends Jak on several missions outside of Haven City. Relative polycythemia is characterized by an elevated PCV in the presence of a normal (or even decreased) total red blood cell mass. Furthermore, antithrombotic doses of aspirin (1 mg/kg per day) may be considered, but there is no proof that it reduces the risk of thrombosis, and higher doses may lead to increased bleeding tendencies. Jak gets thrown into the future and is imprisoned and tortured with dark eco. Granulocyte and platelet counts in the blood would be expected to be increased, but are usually normal. 2 Jewova Dye chwazi kèk moun pou vin zanmi l. Pa egzanp, Abraram se te youn nan zanmi Jewova te genyen (Ezayi 41:8; Jak 2:23). The hematocrit is generally only mildly increased, therefore relative polycythemia is rarely associated with signs of hyperviscosity, and the clinical features of the underlying disorder prevail. Jak 2 used the groundwork laid by the first game and greatly expanded on it. However, his frantic personality dims a little bit when it comes to his work, as he has a sense of pride in his skills and dislikes his expertise being questioned. Krew's mission is in part (o). While Jak was getting artifacts for Onin, Torn was busy also. Vin appears to be elderly given his gray hair and slightly aged skin, though his age is hard to tell due to his frenetic nature. "Every time a second-hand car is bought, it is possible that some of its faults are yet to be discovered; it is a bit like buying a pig in a poke. While channeling Dark Jak, Jak's skin complexion becomes a light gray with a slight purple or blue tint, his hair grows slightly longer, shaggier and spikier, and becomes a darker gray, with his goatee looking somewhat darker, and his eyes grow completely black. A single transformed stem cell gains a selective growth advantage and becomes the predominant source of marrow precursors, and the clonality of the bone marrow cells of human patients with P. vera has been documented. Hence, the diagnosis of P. vera is still based on the exclusion of other causes of erythrocytosis. An increased absolute reticulocyte count in light of a polycythemia supports the exaggerated hematopoietic response and documents the presence of an absolute polycythemia. During Jak II he served as the opposing factor of Baron Praxis, and, while in disguise as an elderly human, an inside-man working for the Underground resistance movement, charged with watching over the Kid … - Duration: 30:27. roblesdegracia 91,121 views. Secondary polycythemia refers to a group of diseases triggered by an exaggerated erythropoietin dependent stimulation of red cell production. In cases that require multiple phlebotomies in a short period, replacement of coagulation factors and albumin with plasma may need to be considered. Jodidos huevos!! He is an averagely tall, lanky human, with protective eyewear, brown overalls, white shirt, and mining boots. 2 Sipoze de moun vin antre nan asanble nou, yonn gen yon bèl rechanj sou li ak yon bag an lò nan dwèt li, lòt la tou pòv ak yon rad chire sou li. Would you like to change your VIN email? Because of the obvious signs of dehydration, relative polycythemia is usually easily recognized and simply corrected with aggressive fluid therapy. We once again follow Jak (and his sidekick Daxter), this time in a new setting. More research is needed in small animals to determine, if such processes are occurring in these polycythemic patients who do not clearly have P. vera. Some clinicians readily equate absolute erythrocytosis with polycythemia vera (P. vera) without considering other differential diagnoses. Vin is a support character in Jak II and Jak 3. LES: Jak is a Fallen Angel and Vin is a scardy cat. Similarly, chronic carbon monoxide intoxication can cause polycythemia with pink mucous membranes. In animals with absolute polycythemia, fluid administration beyond replacement may be associated with cardiopulmonary failure as these animals are completely volume expanded. Vin worked for the city as the operator of the eco grid and other technology. Daxter, his ottsel sidekick, saves him and his first thought is revenge against Baron Praxis, the ruler of Haven City. 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